The Heart Disease Study of Semaglutide in Patients with Type 2 Diabetes (SOUL) is a more extensive and extended phase 3 CVOT presently being conducted, and results are expected in 2024 [55]
Peluso I, Villano DV, Roberts SA, Cesqui E, Raguzzini A, Borges G, et al
This medication effectively reduces food intake by delaying stomach emptying and promoting early fullness
In addition, TMAO may accelerate the process of atherosclerosis and increase the risk of cardiovascular diseases through mechanisms such as promoting inflammation, increasing the expression of scavenger receptors, inhibiting reverse cholesterol transport, and enhancing vascular calcification (Luo et al., 2024)